IEEE Photonics Society

Boston Photonics Society Chapter

Boston Chapter of the IEEE Photonics Society

Imaging Workshop PDF

Wednesday, April 6, 13, 20, 28*, May 4, 2011, 7:00–9:30 PM (* Thursday April 28th)
Located at MIT Lincoln Laboratory – 244 Wood Street, Lexington, MA, 02420, USA

May 4, 2011
8:15 PM

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Computational Microscopy for Imaging the Lung Slides

Prof. Charles A. DiMarzio, Northeastern University, Boston, MA


Prof. Charles A. DiMarzio, Northeastern University, Boston, MA

Abstract:  Optical imaging of biomedical materials holds the promise of non-invasive imaging of medically relevant parameters with sub-micrometer resolution and deep penetration.  However, most tissues thwart the full utilization of these capabilities because of their turbidity.  The problem is particularly severe in lung with diverse spatial scales and large changes in index of refraction. The micro-mechanical properties, the distribution of hemoglobin and oxygen, and the size distribution of alveoli are among the important parameters of the normal and pathological lung.  On the small scale, optical coherence tomography, confocal microscopy, and various types of nonlinear microscopy have enabled high resolution imaging at shallow depths providing information about these parameters.  Extracting all the information from these images requires understanding the propagation of light in complicated heterogeneous media.  In computational microscopy, models of light propagation are used to generate synthetic images in order to better understand the fundamental limits on performance of the various techniques.  Through the development of progressively more complex models and comparison of synthetic images to experimental ones it is possible to develop hardware and algorithms to approach these fundamental limits.  Computational results from finite-difference time-domain calculations will be presented, along with comparison to experimental results.


Biography:  Prof. DiMarzio holds a BS in Engineering Physics from the University of Maine, MS in Physics from WPI, and Ph.D. in ECE from Northeastern.  He spent fourteen years at Raytheon Company, in coherent laser radar for air safety and meteorology.  At Northeastern, he extended his interest in coherent detection to optical quadrature microscopy, a method of quantitative phase imaging, with several applications, most notably assessment of embryo viability.  His interests include confocal microscopy for dermatology and other applications, multi--modal microscopy, spectroscopy and imaging in turbid media, and the interaction of light and sound in tissue.  He led the development of the Keck three-dimensional fusion microscope with seven imaging modes on one instrument.  He is associate professor of electrical and computer engineering and of industrial and mechanical engineering, and a member of CenSSIS, the Gordon Center for Subsurface Sensing and Imaging Systems.


For more information on the technical content of the workshop, contact either:
1) Farhad Hakimi (, Imaging Workshop Committee Co-Chair
2) William Nelson (, Imaging Workshop Committee Co-Chair
3) Reuel Swint (, Imaging Workshop Committee Co-Chair
4) Robert Stephenson (, Boston Photonics Society Chair